association of methylmalonic acidemia and erythema nodosum

Association of Methylmalonic Acidemia and Erythema Nodosum

Association of Methylmalonic Acidemia and Erythema Nodosum

Dear Editor, Methylmalonic acidemia, one of the organic acidemias, is associated with a variety of clinical presentations ranging from very sick newborn infants to asymptomatic adults, regardless of the nature of the enzymatic defect or the biochemical abnormalities. A 6-year-old boy with a past history of methylmalonic acidemia presented to the emergency room with a one-week history of inflamm...

Methylmalonic acidemia

The authors provide an overview of the hereditary methylmalonic acidemias, a group of metabolic disorders with varied clinical presentations. This includes the most severe form of L-methylmalonyl-CoA mutase deficiency, termed mut(o) methylmalonic acidemia, which, together with the less severe deficiencies of L-methylmalonyl-CoA mutase, are the most common causes of methylmalonic acidemia. They ...

Methylmalonic Acidemia.

Methylmalonic Acidemia (MMA) is an inborn error of metabolism that results in accumulation of methylmalonic acid in blood and increased excretion in urine. The effects of MMA vary from mild to life threatening and it usually presents in early infancy. Affected infants can have vomiting, dehydration, hypotonia, developmental delay and failure to thrive. The emergency treatment of the newborn wit...

Erythema nodosum in association with pustular ringworm.

ADDENDUM.-Since the preparation of this paper we have included in our battery of chemotherapeutic agents " epodyl " (I.C.I.) and vincaleukoblastine, on the advice of Mr. L. Walsh, of Atkinson Morley's Hospital, and Mr. K. Till, at Great Ormond Street, respectively. In the five gliomata tested (four astrocytomata and one ependymoma) vincaleukoblastine has proved very cytotoxic but occasionally v...

Erythema nodosum.

Erythema nodosum is the most frequent clinico-pathological variant of the panniculitides. The disorder is a cutaneous reaction consisting of inflammatory, tender, nodular lesions, usually located on the anterior aspects of the lower extremities. The process may be associated with a wide variety of diseases, being infections, sarcoidosis, rheumatologic diseases, inflammatory bowel diseases, medi...